Top 10 Best Selling Supplements in the USA for 2025

1. Organ Supplements

Supplements like beef liver and other organ-based capsules are booming due to demand for nutrient-dense, ancestral nutrition solutions. They’re experiencing near triple-digit growth and are trusted by the paleo and carnivore communities.

2. Creatine (Especially for Brain Health)

Once just a gym staple, creatine is now trending for cognitive support and brain energy, especially among Gen Z and young professionals.

3. Collagen Peptides

Collagen—particularly from grass-fed and marine sources—remains a top seller for skin, joint, and hair health. Collagen supplements that combine with Vitamin D3 and K2 are especially hot now.

4. Adaptogens & Stress Relief Blends

Blends featuring ashwagandha, rhodiola, and theanine are in high demand for stress, mood, and focus support. Adaptogen gummies and powders are among top grossers in the supplement aisle.

5. Women’s Health Supplements (Perimenopause, Hormonal Support)

Supplements for women, with special focus on perimenopause, hormonal balance, and reproductive support, are trending for their targeted, science-backed formulas.

6. Probiotics & Postbiotics

Gut health is big business. The latest high-converting options offer targeted strains and postbiotics for digestive, immune, and mood benefits.

Magnesium (Especially Formulas for Sleep & Kids)

Demand for magnesium—especially sleep blends and formulas targeted at children—is rising, driven by concerns about sleep quality and overall wellness.

8. Protein Powders (Whey & Plant-Based)

Protein remains king for fitness and general wellness. Clean-label, grass-fed, and vegan protein powders like Optimum Nutrition and True Nutrition are best-sellers in US stores and online.

9. Nootropics/Brain Supplements

Nootropics like L-Theanine, Lion’s Mane, and Alpha-GPC are increasingly popular for memory, mental energy, and focus—especially for students and remote workers.

10. Vitamin D + K2 (Immune & Bone Support)

Vitamin D with K2 continues to be a top-converting supplement for immune support and bone health, especially in personalized “wellness stacks” and daily gummies.